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High Protein Low Carb Diet: Complete Macro Guide

A high protein low carb (HPLC) diet combines elevated protein intake with moderate carbohydrate restriction to create an effective approach for fat loss, body recomposition, and metabolic health. Unlike keto, HPLC does not require entering ketosis, and unlike standard dieting, it dramatically increases protein to preserve muscle. This guide covers the optimal HPLC macro split, detailed food lists, sample meal plans, and who will benefit most from this approach.

Key Takeaways
  • HPLC macro split: 40% protein, 20% carbs, 40% fat for most people
  • Protein target: 1.0-1.2g per pound of body weight for maximum muscle preservation
  • Carbs kept moderate: 50-100g daily, focused on vegetables, berries, and small starchy portions
  • Not as extreme as keto: More sustainable, better for gym performance, easier to follow
  • Best for: Fat loss, insulin resistance, sedentary to moderate activity, body recomposition
  • Muscle protection: High protein + resistance training preserves lean mass during a deficit
  • Thermic advantage: Protein burns 20-30% of its calories during digestion
  • Satiety boost: High protein reduces hunger hormones by up to 25%
  • Use our free macro calculator to set your HPLC targets
40%
Protein Target
20%
Carbs Target
40%
Fat Target
50-100g
Daily Carbs

The HPLC Macro Split

The standard high protein low carb macro split is:

HPLC Macro Split
  • Protein: 40% of total calories (1.0-1.2g per pound)
  • Carbohydrates: 20% of total calories (50-100g daily)
  • Fat: 40% of total calories
High Protein Low Carb Split (40/20/40)
40% Protein
20% Carbs
40% Fat

This split provides enough protein to maximize muscle preservation and the thermic effect of food, while keeping carbohydrates low enough to improve insulin sensitivity and reduce hunger. The moderate fat intake supports hormone production and meal satisfaction. For the detailed calculation process, see our how to calculate macros guide.

HPLC Macros by Calorie Level

Understanding exactly how the 40/20/40 split translates to grams at different calorie levels helps you plan your meals. This table shows the precise gram targets for common calorie ranges.

Daily CaloriesProtein (g)Carbs (g)Fat (g)Typical User
1,400140g70g62gSmall female, aggressive cut
1,600160g80g71gAverage female cutting
1,800180g90g80gActive female or smaller male cutting
2,000200g100g89gAverage male cutting
2,200220g110g98gLarger male cutting
2,400240g120g107gVery active or recomposition
2,600260g130g116gMaintenance or lean bulk
2,800280g140g124gActive maintenance

HPLC vs Keto vs Standard Dieting

Understanding how HPLC compares to other popular approaches helps you choose the right diet for your situation. Research from the International Society of Sports Nutrition supports high-protein approaches for body composition.

FactorHPLC (40/20/40)Keto (20/5/75)Standard (30/40/30)
Protein %40% (very high)20-25% (moderate)25-30% (moderate)
Daily carbs50-100g20-50g150-250g
Ketosis requiredNoYesNo
Muscle preservationExcellentGood (if protein adequate)Good (if protein adequate)
SatietyVery high (protein + fat)High (fat-driven)Moderate
Gym performanceGood (some carb fuel available)Reduced for 2-4 weeks, then adaptsBest (full glycogen)
Insulin sensitivityImprovedSignificantly improvedModerate improvement
Food flexibilityModerateLow (very restricted)High
SustainabilityGood for most peopleDifficult for many long-termEasiest to maintain
Thermic advantageHighest (most protein)ModerateModerate
Adaptation periodMinimal (1-3 days)2-4 weeks (keto flu)None
Best forFat loss with muscle preservationInsulin resistance, epilepsy, keto enthusiastsGeneral health, athletes
HPLC 40/20/40
P 40%
C 20%
F 40%
Keto 20/5/75
P 20%
F 75%
Standard 30/40/30
P 30%
C 40%
F 30%

Benefits of High Protein Diets

The elevated protein intake in HPLC provides several powerful advantages, well-documented by research reviewed at Examine.com and the Harvard School of Public Health:

Thermic Effect of Food (TEF)

Protein has the highest thermic effect of any macronutrient. Your body burns 20-30% of protein calories just during digestion, compared to 5-10% for carbs and 0-3% for fat. On a 200g protein diet (800 calories from protein), you burn approximately 160-240 extra calories daily from TEF alone - equivalent to 20-30 minutes of moderate cardio.

Thermic Effect by Macronutrient
Protein
20-30% burned in digestion
Carbs
5-10%
Fat
0-3%

Superior Satiety

Protein is the most filling macronutrient. It reduces ghrelin (hunger hormone), increases peptide YY and GLP-1 (fullness hormones), and slows gastric emptying. People on high-protein diets consistently report less hunger despite eating fewer total calories. This makes HPLC particularly effective for people who struggle with appetite control.

Muscle Preservation During Fat Loss

During a caloric deficit, your body draws energy from both fat stores and muscle tissue. High protein intake signals your body to spare muscle and preferentially burn fat. A study by Helms et al. (2014) found that resistance-trained individuals maintaining protein at 1.0g+ per pound preserved significantly more lean mass than those eating standard protein levels. For detailed protein guidance, see our protein intake guide.

Blood Sugar Stabilization

The combination of high protein and low carbohydrate intake helps maintain stable blood glucose levels. Protein has minimal impact on blood sugar while carbohydrate restriction reduces glucose spikes. This is particularly beneficial for individuals with insulin resistance, prediabetes, or metabolic syndrome.

HPLC Protein Sources Ranked by Quality

Not all protein sources are created equal. The following table ranks the best HPLC protein options by DIAAS score (protein quality), leucine content, and practical considerations. Data sourced from the FAO protein quality report.

Protein SourceDIAAS ScoreLeucine/100gProtein/ServingCarbs/ServingHPLC Rating
Whey Isolate12511.0g27g/scoop1gExcellent
Eggs (whole)1131.1g18g/3 eggs0gExcellent
Chicken breast1082.4g46g/6oz0gExcellent
Beef (sirloin)1062.2g46g/6oz0gExcellent
Salmon1041.8g40g/6oz0gExcellent
Casein protein1048.9g24g/scoop3gExcellent
Greek yogurt1001.0g23g/cup9gVery Good
Cottage cheese971.1g28g/cup8gVery Good
Pork tenderloin972.0g40g/6oz0gExcellent
Shrimp951.9g36g/6oz0gExcellent
Turkey breast932.1g42g/6oz0gExcellent
Tuna (canned)911.7g30g/can0gExcellent
Tofu (firm)920.8g18g/6oz3gGood
Tempeh890.9g31g/cup9gGood
Edamame710.7g18g/cup14gModerate

High Protein Low Carb Food List

Here are the best foods for an HPLC diet, organized by primary macronutrient contribution:

FoodServingProteinCarbsFatCaloriesNotes
Chicken breast6 oz46g0g4g220HPLC staple, extremely lean
Salmon (wild)6 oz40g0g11g260Omega-3s, vitamin D
Eggs (whole)3 large18g0g15g210Complete protein, choline
Ground turkey (93%)6 oz42g0g12g280Versatile, moderate fat
Sirloin steak6 oz46g0g14g310Iron, B12, zinc
Greek yogurt (nonfat)1 cup23g9g0g130Probiotics, calcium
Cottage cheese (2%)1 cup28g8g5g185Casein protein, great before bed
Whey protein1 scoop25g3g1g120Fast-absorbing, convenient
Shrimp6 oz36g0g2g170Very lean, selenium
Pork tenderloin6 oz40g0g6g220Lean pork cut, thiamine
Tuna (canned in water)1 can (5 oz)30g0g1g130Budget-friendly, limit to 2-3x/week
Cod fillet6 oz40g0g2g180Very lean white fish
Egg whites1 cup26g0g0g126Pure protein, no fat
Almonds1 oz6g6g14g164MUFA, vitamin E, magnesium
Avocado1/2 medium2g6g12g120Fiber, potassium, MUFA
Olive oil1 tbsp0g0g14g120MUFA, polyphenols
Cheese (cheddar)1 oz7g0g9g113Calcium, protein, B12
Broccoli1 cup3g6g0g31Fiber, vitamin C, low-carb
Spinach2 cups raw2g2g0g14Iron, folate, nearly zero carbs
Cauliflower1 cup2g5g0g27Versatile rice/mash substitute
Berries (mixed)1/2 cup1g10g0g40Antioxidants, lowest-sugar fruit
Peppers (bell)1 medium1g6g0g30Vitamin C, versatile cooking
Asparagus6 spears2g4g0g20Folate, low-carb side dish
Tofu (firm)6 oz18g3g9g165Plant-based protein option
Walnuts1 oz4g4g18g185Omega-3 ALA, brain health
Peanut butter (natural)2 tbsp8g6g16g190Protein + fat source
Zucchini1 cup1g3g0g17Pasta substitute, very low carb
Mushrooms1 cup3g3g0g22Vitamin D (if sun-exposed)
Dark chocolate (85%+)1 oz2g13g12g170Occasional treat, antioxidants

Low-Carb Vegetable Carb Counter

When following HPLC, vegetables become a critical carb source. This table helps you budget your carb intake across different vegetables.

VegetableServing SizeNet CarbsFiberHPLC Servings/Day
Spinach2 cups raw0.8g1.4gUnlimited
Lettuce (romaine)2 cups0.6g1.0gUnlimited
Cucumber1 cup sliced2.0g0.5gUnlimited
Celery2 stalks1.0g0.6gUnlimited
Zucchini1 cup2.0g1.0g3-4
Asparagus6 spears2.4g1.2g3-4
Broccoli1 cup3.6g2.4g2-3
Cauliflower1 cup2.8g2.0g2-3
Green beans1 cup4.0g2.7g2
Bell pepper1 medium4.3g1.7g2
Brussels sprouts1 cup4.6g3.3g2
Cabbage1 cup shredded3.0g2.0g2-3
Tomato1 medium4.0g1.5g2
Onion1/4 cup diced3.0g0.5g1-2
Carrots1 medium5.0g1.7g1

Sample HPLC Meal Plan: 1,600 Calories

This plan targets approximately 160g protein, 80g carbs, and 71g fat - suitable for a smaller individual or a woman on a moderate cut.

MealFoodsProteinCarbsFatCal
Breakfast (7am)3 eggs scrambled, 1/2 avocado, 1 cup spinach20g6g22g300
Lunch (12pm)6 oz chicken breast, large mixed salad, 1 tbsp olive oil, 1/2 cup berries48g18g16g410
Snack (3pm)1 cup Greek yogurt (nonfat), 10 almonds27g12g10g245
Dinner (6:30pm)6 oz salmon, roasted cauliflower + broccoli, 1 tsp butter42g10g16g350
Evening (9pm)1 scoop casein protein, 1 tbsp peanut butter28g5g9g215
TOTAL165g51g73g1,520
1,600 Cal Plan - Daily Protein Distribution
20g
48g
27g
42g
28g
BreakfastLunchSnackDinnerEvening

Sample HPLC Meal Plan: 2,200 Calories

This plan targets approximately 220g protein, 110g carbs, and 98g fat - suitable for an active male or larger individual on HPLC.

MealFoodsProteinCarbsFatCal
Breakfast (7am)4 eggs, 2 slices turkey bacon, 1/2 avocado, 1 cup peppers36g10g30g450
Lunch (12pm)7 oz sirloin steak, large salad, 1 tbsp olive oil, 1/2 cup sweet potato52g22g20g475
Pre-Workout (3pm)1 scoop whey, 1 medium apple25g25g1g210
Dinner (6:30pm)7 oz chicken thigh (skinless), zucchini noodles, pesto (2 tbsp), mushrooms48g8g22g420
Snack (8:30pm)1.5 cups cottage cheese (2%), 1 oz walnuts38g14g24g420
Evening (10pm)Protein shake, 1 tbsp almond butter28g6g11g235
TOTAL227g85g108g2,210

For additional meal ideas and food sources, see our best foods for macros and meal prep for macros guides.

HPLC Weekly Meal Prep Template

Batch cooking is essential for HPLC success. Here is a weekly prep template that provides variety while keeping meal prep efficient.

Prep ItemQuantityProteinsStorageUse For
Grilled chicken breast3 lbs~350g total5 days fridgeSalads, stir-fry, wraps
Hard-boiled eggs12~72g total7 days fridgeBreakfast, snacks
Ground turkey patties2 lbs~180g total4 days fridge, 3 months frozenQuick lunches, dinners
Baked salmon portions1.5 lbs~160g total3 days fridgeLunch, dinner
Roasted vegetables6 cups-5 days fridgeSide dishes
Cauliflower rice4 cups-5 days fridgeRice substitute
Greek yogurt portions5 cups~115g total7+ days fridgeBreakfast, snacks
Pre-portioned nuts7 oz bags~42g total2 weeksSnacks

Who Should Consider HPLC

HPLC is particularly effective for specific populations and goals, as supported by the NIDDK and Dietary Guidelines:

Ideal HPLC Candidates
  • Insulin resistance or prediabetes: Lower carb intake improves blood sugar control and insulin sensitivity.
  • Sedentary to moderately active individuals: People who do not perform intense exercise do not need large amounts of carbohydrates.
  • Fat loss with muscle preservation: The combination of high protein and caloric deficit is optimal for maintaining lean mass.
  • People who find protein filling: Some individuals naturally feel more satisfied with protein-rich meals.
  • Those who have plateaued on standard diets: Switching to HPLC can restart progress.
  • Body recomposition: Elevated protein supports muscle protein synthesis even in a mild deficit.

Who Should NOT Use HPLC

HPLC is not the optimal choice for everyone. Consider alternatives if you fall into these categories:

HPLC May Not Be Right For
  • Endurance athletes: Runners, cyclists, and swimmers need 50-65% of calories from carbohydrates. See our macro calculator for athletes.
  • High-volume strength training: Bodybuilders doing 6+ sessions per week benefit from higher carb intake (40%+).
  • People with kidney disease: High protein intake increases the kidneys' workload. Consult your doctor. The NIDDK provides kidney health resources.
  • Those who enjoy high-carb foods: If restricting carbs feels unsustainable, see our flexible dieting guide.
  • Pregnant or breastfeeding women: These individuals have increased carbohydrate needs.

HPLC by Body Type

Your natural body type may influence how you respond to different macro ratios. Use this as a starting point, then adjust based on results.

Body TypeCharacteristicsSuggested HPLC VariantAdjustment Tips
EctomorphNaturally lean, fast metabolism35/25/40 (more carbs)May need higher carbs for energy; focus on calorie density
MesomorphNaturally muscular, moderate metabolism40/20/40 (standard)Responds well to standard HPLC; adjust based on training volume
EndomorphGains weight easily, slower metabolism45/15/40 (lower carbs)May benefit from even lower carbs; monitor energy levels
Ecto-mesoLean but can build muscle38/22/40Slightly more carbs around training; standard HPLC otherwise
Endo-mesoMuscular but gains fat easily42/18/40Lower carbs on rest days; strategic carbs around workouts

Carb Sources for HPLC

With only 50-100g of carbs daily, every gram counts. Focus on the most nutrient-dense, fiber-rich carb sources:

  • Non-starchy vegetables (unlimited): Broccoli (6g/cup), spinach (1g/cup), cauliflower (5g/cup), bell peppers (6g/medium), zucchini (3g/cup), asparagus, mushrooms, leafy greens
  • Berries (in moderation): Strawberries (12g/cup), blueberries (21g/cup), raspberries (15g/cup) - choose berries over other fruits for the lowest sugar-to-fiber ratio
  • Small starchy portions (around workouts): 1/2 cup sweet potato (13g), 1/3 cup oats (18g), 1/3 cup rice (15g) - time these around training for maximum benefit
  • Dairy carbs: Greek yogurt (7-9g/cup), cottage cheese (6-8g/cup) - these come bundled with high protein
  • Avoid: Bread, pasta, cereal, juice, candy, and other high-carb, low-nutrient foods that would consume most of your daily carb budget in a single serving

For a deeper understanding of carbohydrate management, read our carb calculator guide.

HPLC and Exercise Performance

Exercise performance on HPLC depends heavily on the type and intensity of activity, as described by the American College of Sports Medicine:

Activity TypePerformance ImpactStrategyCarb Timing
Walking / light cardioNo impactNo adjustment neededN/A
Moderate weight training (3-4x/week)Minimal impactTime 20-30g carbs pre-workout60-90 min before
High-intensity intervals (HIIT)Moderate reductionAdd 15-20g fast carbs pre-workout30-45 min before
Heavy compound liftingNoticeable strength decreaseConsider 30-40g carbs around trainingPre and post workout
Endurance (60+ min)Significant performance dropHPLC not recommended; increase carbs to 40%+Before, during, after
Recreational sportsMild reductionSmall carb snack 30-60 min before30-60 min before
Yoga / PilatesNo impactNo adjustment neededN/A
CrossFit / functional trainingModerate to significantFront-load carbs around WODsPre-workout priority

The key strategy: concentrate your limited carbohydrate intake around your training window. Have your largest carb serving 1-2 hours before your workout and a smaller carb + protein serving immediately after. This maximizes glycogen availability when you need it most while staying within your HPLC targets.

HPLC Carb Timing Strategy

Strategic carb placement can optimize performance even with limited carbohydrate intake.

Optimal Carb Distribution on Training Days (80g total)
Morning
10g
Veggies only
Pre-Workout
30g
Oats or sweet potato
Post-Workout
25g
Rice + fruit
Evening
15g
Veggies + berries

HPLC for Metabolic Health

Beyond fat loss, HPLC offers significant metabolic benefits. Here are the key markers that typically improve on an HPLC diet:

MarkerTypical ImprovementTimeframeMechanism
Fasting insulin20-40% reduction2-4 weeksReduced carb intake lowers insulin demand
Fasting glucose5-15% reduction2-4 weeksLower carbs, improved insulin sensitivity
HbA1c0.3-0.8% reduction8-12 weeksSustained blood sugar control
Triglycerides15-30% reduction4-8 weeksReduced carb-to-fat conversion
HDL cholesterol5-15% increase8-12 weeksHigher fat intake, lower refined carbs
Blood pressure3-8 mmHg reduction4-8 weeksWeight loss, reduced insulin
Waist circumference2-4 inches reduction8-16 weeksPreferential visceral fat loss

Long-Term Sustainability

HPLC is more sustainable than keto for most people because it allows a wider range of foods and does not require maintaining strict ketosis. However, any diet's long-term success depends on these factors:

  • Protein variety: Rotate between chicken, fish, beef, eggs, dairy, and plant proteins to avoid food fatigue. Eating chicken breast at every meal gets old fast.
  • Cooking skills: Learning to prepare protein-rich meals that taste great is essential. Invest time in marinades, spice blends, and cooking techniques.
  • Social flexibility: HPLC allows more social eating than keto. At restaurants, choose any protein-based entree and substitute starchy sides for extra vegetables. See our flexible dieting guide for strategies.
  • Periodic adjustments: After 8-12 weeks on HPLC, consider a maintenance phase with slightly higher carbs (30%) for 2-4 weeks before resuming. This prevents metabolic adaptation and provides a psychological break. Our maintenance macros guide covers this transition.
  • Listen to your body: If you feel chronically fatigued, cold, or lose interest in food, your carbs may be too low for your activity level. Increase by 20-30g and reassess.

Common HPLC Mistakes to Avoid

MistakeProblemSolution
Not tracking fat intakeEasy to overconsume calorie-dense fatsWeigh oils, nuts, and cheese; track everything
Insufficient vegetablesMissing fiber, vitamins, mineralsEat 4+ cups of non-starchy veggies daily
Skipping protein at breakfastHunger spikes later in the dayStart with 30+ grams of protein
Ignoring electrolytesFatigue, headaches, crampsIncrease sodium, potassium, magnesium
Too few caloriesMetabolic adaptation, muscle lossMaintain at least a 20-25% deficit maximum
All protein from shakesMissing whole food nutrientsLimit shakes to 1-2 daily; prioritize whole foods
Avoiding all fruitMissing antioxidants, varietyInclude 1/2 cup berries daily
Weekend carb bingesUndermines weekly progressPlan higher-carb meals strategically

Transitioning to HPLC

A gradual transition helps minimize side effects and improves long-term adherence.

WeekCarb TargetProtein TargetFocus
Week 1150g (35%)30%Reduce refined carbs, increase protein portions
Week 2120g (28%)35%Eliminate sugary drinks, add protein snacks
Week 390g (22%)38%Replace starchy sides with vegetables
Week 4+50-80g (20%)40%Full HPLC implementation

Frequently Asked Questions

A high protein low carb diet uses a macro split of approximately 40% protein, 20% carbs, and 40% fat. It emphasizes protein intake of 1.0-1.2g per pound while keeping carbohydrates at 50-100g per day. This is more moderate than keto and provides significantly more protein than standard diets.

HPLC allows 50-100g carbs daily (vs keto's 20-50g) and prioritizes protein at 40% (vs keto's 20-25%). HPLC does not require ketosis and is generally more sustainable, better for gym performance, and superior for muscle preservation. Keto relies on fat as the primary fuel source while HPLC uses a mix.

Aim for 1.0-1.2g of protein per pound of body weight, or approximately 40% of total calories. For a 180 lb person eating 2,000 calories, that equals roughly 180-216g of protein per day. If significantly overweight, base your target on goal body weight.

You can maintain muscle and build some on HPLC, especially as a beginner. However, optimal muscle building typically requires more carbohydrates (30-40%) to fuel intense training. If maximum muscle gain is your primary goal, a moderate-carb approach is generally more effective.

HPLC is ideal for people with insulin resistance, sedentary to moderately active individuals, those focused on fat loss with muscle preservation, people who find protein satiating, and anyone who has plateaued on standard diets. It is less suitable for endurance athletes and high-volume lifters.

Focus on non-starchy vegetables (broccoli, spinach, peppers, cauliflower), berries in moderation, and small portions of sweet potato, oats, or rice around workouts. Avoid high-carb, low-nutrient foods that would consume most of your daily carb budget in one serving.

For most healthy adults, HPLC is safe for extended periods. High protein is not harmful to healthy kidneys. The moderate carb restriction (50-100g) provides enough for brain function and moderate exercise. Those with existing kidney disease should consult a doctor first.

No. The high protein component is specifically designed to prevent muscle loss. Research shows protein at 1.0g/lb+ combined with resistance training preserves nearly all lean mass even during significant deficits. HPLC is one of the best approaches for maintaining muscle during fat loss.

Low-to-moderate activities are largely unaffected. High-intensity efforts may suffer because muscle glycogen from carbs fuels those activities. Time your limited carbs around workouts (20-30g pre-workout) to minimize performance impact.

Yes, but it requires more planning. Key sources include eggs, Greek yogurt, cottage cheese, whey protein, tofu, tempeh, and seitan. It is more challenging because many plant proteins also contain significant carbs. Focus on dairy-based and egg-based proteins plus supplements.

Gradually increase carbs by 10-15g per week until you reach 50-100g daily. Simultaneously increase protein to 40% of calories. You may experience some water weight gain as glycogen stores replenish - this is normal and temporary. Most people find HPLC easier to sustain than strict keto.

Essential supplements include electrolytes (sodium, potassium, magnesium) especially in the first few weeks, vitamin D if sun exposure is limited, and omega-3s if you do not eat fatty fish regularly. Whey protein is helpful but not required if you meet protein targets through food.

Most people notice reduced hunger within 3-5 days due to high protein intake. Visible fat loss typically begins within 2-3 weeks when combined with a caloric deficit. Significant body composition changes require 8-16 weeks of consistent adherence.

Yes, HPLC can significantly improve insulin sensitivity. The reduced carbohydrate intake lowers insulin demand, while high protein helps stabilize blood glucose levels. Studies show moderate carb restriction combined with adequate protein can reduce fasting insulin and HbA1c.

While HPLC naturally promotes satiety, counting calories improves results. High-protein foods like nuts, cheese, and fatty meats are calorie-dense and easy to overconsume. Use our macro calculator to get your targets, then track consistently for best outcomes.

Calculate My HPLC Macros

Research and References

This guide is based on peer-reviewed research and established nutritional science:

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